Board Thread:General Discussion/@comment-6381700-20130224192556/@comment-6881629-20150525203245

The two spheres almost definitely don't loose the quest item tag you can only be guarantee to get rid of them on a PC using the console command -

player.removeitem 0003532C 2

On a console you could try one of the quests that takes your inventory away or going to jail and escaping then leaving them behind in the chest, it might not work though.