Board Thread:Lore Discussion/@comment-4840601-20140825201737/@comment-24045142-20140825202946

There are a few in-game sources that state that an Elder Scroll is not easily destroyed. Additionally, I don't know if there truly are any ways to even damage it. I'd surmise that dragonfire might, or (as you suggest) powerful Daedric magic. Other than that I can't think of anything else that could come close.