User blog comment:Blood Reaper/Skyrim 1.5 Update + Video/@comment-3338515-20120321041413/@comment-4394107-20120321163612

Firstly, 320 hours is a problem in itself. I don't think the game was ever designed to be that large. My longest playthrough (with every main/unique side quest completed, lvl 81) is around 130 hours. There are some problems noted with activators in dungeon that seem to be random, but nothing like what you describe.

If you're using an old model 360 (pre-slim) try dusting out the fan to prevent disc read errors. Also clean the disc and disc tray as best you can. But honestly I don't think Bethesda will fix this; it sounds like a problem exlcusive to you.

Also, 320 hours is over 13 days of total play time. GAH.