User blog comment:Timeoin/Is 'Redguard' the next Skyrim DLC?/@comment-122.59.164.92-20130109221530/@comment-3076045-20130109224253

Well, just so you know, the VERY EARLIEST game so far happened in the Second Era. (You couldn't explore more than the fortress, though). There were two games in the LATE second era. Most of them take place in the late Third Era (or Fourth Era, as with Skyrim). There's NEVER been a game set in the First Era, though.

The biggest historical "gap" per se would be the Interregnum, which is when TES:Online is being set.