Board Thread:General Discussion/@comment-10631366-20130609052307/@comment-4787430-20130611174730

Bethesda included the console for those who want to mod or debug their current saved games. The Creation Kit is all of Skyrim's data, including those test cells. If you disabled an NPC it's not going to remove them from the game data, it's only going to remove them from your current saved game file. You can't permanently remove anything in the game data by using console commands, it will always be in the master file (which can't be modified).

You could end up messing up your saved game though if you start disabling essential NPCs, especially if you don't know how to enable them again. So, using console commands isn't recommended for those that aren't sure what they are doing.