User blog comment:Harold Burned-Mane/My Top 15 Favorite Skyrim Mods/@comment-9062114-20131012215811/@comment-17114085-20131012222120

Most mods are safe to use, install and unsinstall at will. Those that change scripts though are a little more dangerous, as Skyrim saves scripts on your save file, so even if you uninstall the mod the scripts will stay, which will make your save unstable. An example of a mod like this is the Dragon Combat Overhaul. So when using script changing mods its better to start a new game and keep the mod throughout your whole Playthrough so as to make sure that your save doesn't become unstable.

When installing a mod its better to use a program to safely install/uninstall it, the Steam workshop is completely safe to use (and is how I got into mods for Skyrim, as I, much like yourself, was affaid of corrupting something), when downloading mods from the Nexus its better to use their program, the Nexus Mod Manager.

Just remember to read the mod description to make sure you have all requirements to run the mod, and read the install instructions, to make sure you do everything correctly(using a Mod Manager makes installing super easy). Always check to see if the mod you are downloading doesn't conflict with any other mod you already have installed(or else your game could/will crash).

If you do become interested in using mods then Happy Moding :)

Talos guide you-Harold Burned-Mane