User blog comment:The Rim of the Sky/Bethesda Hosting First-ever E3 Conference/@comment-1600847-20150214123432

My belief on what's going to be announced (since Battlecry and Doom 4 have been announced already I won't mention them):

Rage 2 or Prey 2: Neither did very well, only doing averagely, so I highly doubt they'll be the focus.

Dishonored 2 or Wolfenstein: Since Bethesda is only publishing, not making, these franchises, I highly doubt they'll hold their first ever conference just to announce another company's game. They might be mentioned, but won't be the highlight. Plus, it's way too early for a Wolfenstein sequel.

Quake: That'd be announced at Quakecon.

Elder Scrolls 6: It's been a little over 3 years since Skyrim, so later this year or 2016 is more likely. Plus, ESO just came out. Hate it or like it, Bethesda is involved in it, however small that involvement may be.

So, that leaves Fallout 4 or a brand new IP as the most likely announcements.