User blog comment:Apples822/You can play Skyrim till the cows freeze over.../@comment-4493694-20111110003128/@comment-24.115.210.126-20111110003631

Considering the game isnt out yet I can't answer that to good. But I can say in Oblivon (which is the 3 or 4th in the series) only made a few references to the previous games. So if they follow that plan you should be able to jump right in.