User blog comment:Ninja Tank Nick/Reason I think the dragonborn Could not be emperor of Tamerial/@comment-71.218.244.183-20120329194014

Technically you don't have to be an imperial to be emperor. Look at Katariah Septim. She was a dunmer who was married to the emperor, Pelagius the Mad. When his mental health deteriorated, Katariah took over ruling the empire, and continued to rule after his death. Her son, Cassynder took over after her death.

I doubt the Dragonborn will ever rule the empire, because it doesn't fit the story, not because of race. Bethesda could find a way, but I still wouldn't hold my breath.