Board Thread:Skyrim/@comment-107.77.97.120-20170923215754/@comment-26213507-20170923221307

Most quests that involve a dungeon are randomized, so clearing out a specific area doesn't usually have a negative impact on the game. After a few weeks in-game, the dungeon will respawn, so most can be cleared more than once.

Quests that involve a location tend to start when you get inside, and ones that are specific to a main quest (like Irkngthand) cannot be accessed until that quest anyway.

Overall, feel free to adventure through them every so often. There are only a few bugs related to locations, so it's not a very big problem.