Found in Windhelm, it serves as a museum of various esoteric items, collected by the proprietor, Calixto, and his sister during their travels. After inheriting a large sum of money from their parents, the two traveled across Tamriel. The House of Curiosities displays the treasures they found along the way. After the death of his sister, Calixto opened the shop. Most of the displayed items are rare alchemical ingredients. Among them are Ancient Nord embalming tools, the Book of Fate, The Dancer's flute and Ysgramor's Soup Spoon. The player can tour his shop at the price of 2 gold. In Calixto's bedroom, there is a Cooking Spit. The owner wakes at 8 AM and sleeps at 12 PM, and the door to the facility is protected by a Master-level lock.
- After completing Blood on the Ice, the house remains unoccupied, and its contents are flagged as "steal". It has more than enough valuable items that respawn every few game days to complete a Thieves Guild (Skyrim) Bedlam job in Windhelm.
- Sometimes this building can only be accessed by breaking in. If successful, Calixto will not offer a tour and will demand the player to leave before calling the guards. This in turn creates complications with the Blood on the Ice Quest when one is told to go talk to him.