Spyrocks, are you...are you high? Again? Or were you ever not high?
I'm sorry...just...these topics...they make no sense
You can't kill Sanguine without destroying his entire Daedric Realm, because he is his entire Daedric Realm. And even then it's an iffy thing. In any case, it's way beyond the capabilities of the LDB. I don't think even other Daedric Princes can do it, or else they probably wouldn't have had to Sheogorathify Jyggalag. And someone probably would have taken out Dagon, since I'm pretty sure at least a few of the DPs have a fair amount invested in Mundus.
You can't kill Sanguine for one very simple reason: he's a Daedric Prince!!!!!! He's a god, you can't just kill a god like figure. Not even if your as powerful as the Dragonborn. Plus, he's immortal. If he was killed by some greater than god force, he would come back.