Perk's I use on most character's are the Extra pocket's perk in the Pickpocket skill for extra carry weight and the Magic resistance perk's in the Alteration skill for fighting Mage's / Dragon's. The perk's in the Speech skill for selling item's and having more shop gold can be helpful especially early on.
Alduintheworldeater10 wrote: Should I get the destruction perk that disintegrates enemies or not?
Don't bother, unless you really need that 15% health reduction for all enemies.
Really, you should up destruction fully, then make a dual enchanted chaos lifeleech sword. The destruction school will help you understand why.
I do encourage putting some perks into one handed. A heavy armored mage should learn how to use a sword. Its very important to use melee backup just in case somebody comes up to your face. Plus its actually easier to attack with spells at short range.